Targeting Tumor Angiogenesis: Molecular Biology and Clinical Practice

Chairs: R. Herrmann, Basel / N. Saijo, Tokyo

Biomarkers profile and clinical factors in selecting patients
A.B. Sandler, Portland
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Imaging in targeted therapy
C. Fink, Mannheim
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Management of toxicity of anti-angiogenic/anti-EGFR agents
J. Heymach, Houston
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Integrin inhibitors
S. Peters, Lausanne
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Vascular disrupting agents
J.Y. Doulliard, Nantes
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Anti-angiogenic TKI’s
U. Gatzemeier, Großhansdorf
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Molecular biology
E. Voest, Utrecht

Novel Agents I

Chairs: W. Eberhardt, Essen / T. Le Chevalier, Paris

Heat shock protein targeting agents
K. O’Byrne, Dublin
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Histone deacetylase inhibitors
S. Ramalingam, Atlanta
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PARP1-inhibitors
J.-C. Soria, Paris
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Dendritic cell recruitors and activators
A. Y. Chang, Singapore
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Vaccine therapy
J. Vansteenkiste, Leuven
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Pro-apoptotic agents
F. R. Khuri, Atlanta
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Mannheim Lilly Oncology Lecture

Targeted therapy: how to clinically develop new agents and treatment strategies based on pre-clinical information
P. Bunn, Denver
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Targeting the Epidermal Growth Factor Receptor (EGFR): Molecular Biology and Clinical Practice

Chairs: N.Thatcher, Manchester / K. Syrigos, Athens

Molecular biology of the EGFR-pathway
A. F. Gazdar, Dallas
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Clinical and molecular predictors of EGFR-TKI sensitivity
F. A. Shepherd, Toronto
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Mechanism of drug resistance and how to overcome first generation EGFR- TKI failure
P. A. Jänne, Boston
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EGFR-TKI first-line therapy: diagnostic assessment and drug selection
T. Mok, Hong Kong
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EGFR-assessment in prospective clinical trials
R. Dziadziusko, Gdansk
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Treatment duration and sequencing of EGFR-TKI inhibitors
F. Cappuzzo, Livorno
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EGFR-targeting antibodies: clinical and molecular sensitivity predictors
R. Pirker, Vienna
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EGFR-targeting antibodies in combination with radiotherapy
F. Mornex, Lyon
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NSCLC: Relevance of Treatment Prediction by Histology for Early and Advanced Disease

Chairs: F. Blackhall, Manchester / C. Manegold, Mannheim

Relevance of TS testing: British experience
K. Kerr, Aberdeen
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Pharmacogenomic guided treatment strategies for early NSCLC
G. V. Scagliotti, Torino
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Pemetrexed (Alimta therapy): duration and frequency
C. Belani, Hersey
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Gene Expression/Tumor Histology Guided Therapy

Chairs: N. van Zandwijk, Sydney / J. Niklinski, Bialystok

Molecular basis
H. Allgayer, Mannheim
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Proteomics and outcome prediction
D. P. Carbone, Nashville

Rationale for Genomic Guided Molecular Therapy in Lung Cancer
A. Potti, Durham / N. Ready, Durham
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MicroRNA signatures and outcome prediction
P.-C. Yang, Taiwan
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TS-expression and sensitivity to anti-folates
G. V. Scagliotti, Torino
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ERCC1, RRM1, and BRCA1-gene expression and outcome prediction
G. Bepler, Detroit
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Tumor histology and clinical outcome
C. Manegold, Mannheim
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Novel Agents II

Chairs: P. Postmus, Amsterdam / J. S. Lee, Seoul

ACT, MAPK, MEK-inhibitors
A. Adjei, Buffalo
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ALK, MET-inhibitors
R. Stahel, Zürich
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SRC-targeting agents
O. Gautschi, Bern
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m-Tor-inhibitors
L. Crinò, Perugia
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Insulin growth factor receptor targeting agents
L. Paz-Ares, Sevilla
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Tabacco Control and Lung Cancer Prevention

(supported by an Eli-Lilly unrestricted educational grant)

Chairs: L.R. Pilz, Heidelberg / K. Park, Seoul

WHO perspectives in reducing lung cancer mortality
A. Ullrich, Geneva
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Tobacco control policy in Poland
J. Jassem, Gdansk
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Smoking cessation in women
C. M. Dresler, Littler Rock
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Female gender as a prognostic and predictive factor
S. Novello, Torino
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New targets for chemoprevention
Y. E. Miller, Denver
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Chemoprevention of high risk patient populations
N. van Zandwijk, Sydney
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2010 Challenges in Thoracic Oncology I

Chairs: D. H. Grunenwald, Paris / C. Zhou, Shanghai

Implications of the new TNM system for the surgical management of early stage lung cancer
P. Goldstraw, London
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Implications of the new TNM system for modern imaging
S. Schönberg, Mannheim / C. Fink, Mannheim
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Minimally invasive non-surgical methods for staging lung cancer
F. Herth, Heidelberg
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Adjuvant chemotherapy
B. Besse, Paris
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Induction chemotherapy
P. van Schil, Antwerp
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Advanced NSCLC: maintenance therapy
C. Belani, Hersey
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2010 Challenges in Thoracic Oncology II

Chairs: P. Hohenberger, Mannheim / E. Smit, Amsterdam

Stereotactic radiation therapy for stage I NSCLC
F. Wenz, Mannheim
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Chemo-radiation
D. de Ruysscher, Maastricht
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Is thymic carcinoma a specific entity?
A. Marx, Mannheim / P. Ströbel, Mannheim
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Malignant pleural mesothelioma: extension of surgery
W. Weder, Zurich
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Malignant pleural mesothelioma: new drug development
D. Fennell, Belfast
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SCLC: Combined modality therapy in limited stage disease
A. Ardizzoni, Parma
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